From: Guy R. Schenker, D.C. December, 1997 Dear Doctor, SUGAR BABIES! That's what all too many of my patients are -- and I don't hesitate to tell them so. And where does the sugar baby lifestyle lead? To: - fatigue - over weight or under weight - hypoglycemia or diabetes - anxiety, depression and mood swings - premature aging Which is to say that being a sugar baby usually leads to a glucogenic or ketogenic metabolic imbalance. You learned in last month's Letter about the inadequate energy production of your glucogenic and ketogenic patients and how this energy insufficiency leads to physical devastation, mental depletion, and emotional failure. We also took you in last month's Letter on a step-by-step walk through the glucogenic/ketogenic page of your Quick Reference Guide. You learned that your glucogenic/ketogenic analysis relates to three biochemical abnormalities typical of these patients: - deficient oxidation activity - abnormal carbon dioxide levels - abnormal serum pH Your QRG protocol gives you the means to evaluate each of your patients for this important metabolic balance in a matter of seconds. Now look once again at the glucogenic/ketogenic page of your QRG for an understanding of how and why you recommend supplementation for your glucogenic and ketogenic patients. Let us look at the glucogenic side of the page first. - 2 - At the top of your glucogenic supplement list is, of course, Oxygenic G. Look at a bottle of Oxygenic G and ask yourself why is each of these ingredients included in Oxygenic G? Then, ask yourself another even more important question -- why are certain common vitamins and minerals not included in Oxy G? The answers to these questions are quite simple, really. Oxygenic G includes a combination of amino acids, vitamins, minerals and trace minerals to achieve a desired effect -- to increase your glucogenic patients' oxidative energy production by facilitating the ketogenic metabolic pathways in which they are deficient; and, to also elevate the low serum pH typical of your glucogenic patients. At the same time we are very careful to include in Oxygenic G nothing to push your glucogenic patients deeper into the glucogenic metabolic pathway in which they are stuck. So, for example, you will see in Oxy G vitamin B3 as niacinamide and vitamin B12 because they so effectively promote alkaline ketogenic metabolism; but, you will see absolutely no vitamin B3 as nicotinic acid, nor will you see any vitamin B6 because these B vitamins stimulate the acid carbohydrate metabolism that is excessive in your glucogenic patients. You will find in Oxygenic G the antioxidant vitamin A as palmitate and the bioflavenoids rutin and quercetin -- but you will see none of the acid antioxidants like vitamin C. What other goodies do you find in Oxy G? You will find ribonucleic acids which satisfy your glucogenic patients' need for nucleic acids. You will also find L-carnitine which gives your glucogenic patients a big boost in their ability to metabolize the fatty acids which they so desperately need. There are four other potently ketogenic amino acids provided in your Oxygenic G which help move your glucogenic patients into the beta hydroxy butyric acid metabolic pathway so as to increase their energy production. Nowhere but from NUTRI-SPEC can you find a product designed with such nutritional specificity. No way but with your NUTRI-SPEC testing system can you determine a patient's need for such a specific supplement. As powerful as Oxygenic G is, its benefit to your glucogenic patients can be enhanced further with judicious use of the other supplements listed in your QRG. Looking further down the list you will next see the amino acids tyrosine and phenylalanine. These are the major ketogenic amino acids and are already included in your Oxygenic G. However, you will find patients whose symptomatic picture will clear up more quickly if you give higher dosages of these amino acids. - 3 - These amino acids are particularly beneficial for your patients suffering from allergies, depression, and fatigue. There is one important caution in the use of these amino acids, however. You note that your QRG specifies to not give these amino acids to a glucogenic patient who has a large pupil. Why is this? The reasoning is simple. All your glucogenic patients have a hypoglycemic tendency. In some of these patients their sympathetic system will make a valiant attempt to compensate for the low blood sugar. Some of these patients will produce tremendous amounts of the catecholamines epinephrine and norepinephrine in their struggle to maintain normal blood sugar. In other words, these patients will be continuously in a state of sympathetic over-reactivity in compensation for their glucogenic blood sugar. Tyrosine and phenylalanine are precursors to catecholamines and therefore are contraindicated in these glucogenic patients. If you make the mistake of giving tyrosine or phenylalanine to glucogenic patients with a strong sympathetic compensation you will tend to exacerbate many of their glucogenic symptoms including nervousness, anxiety, and insomnia. What else can you do supplementally for your glucogenic patients? Next in your QRG you see the amino acid methionine. We have described methionine in detail in recent Letters. To review -- methionine is lipotrophic. This means it helps the liver process and eliminate excess cholesterol and triglycerides. This is particularly important in some of your glucogenic patients because in some individuals the glucogenic preponderance of carbohydrate metabolism leaves a deficiency of fat metabolism. This inadequate metabolism of fats can lead to elevated cholesterol and triglycerides. Furthermore, many glucogenic patients have inadequate liver capacity for eliminating excess fats. This is due largely to congestion of the biliary system and liver resulting from excess carbohydrate and insufficient fat intake relative to that glucogenic patient's need. So -- give methionine to all your glucogenic patients with elevated blood fats. Methionine is also beneficial for your glucogenic patients with allergies because of its antihistamine effect. The final supplement listed in your QRG for glucogenic patients is glutamine. We talked at great length about glutamine in the October Letter and suggest that you review that important information now. The highlight of glutamine's use for your glucogenic patients is in its ability to enhance biliary function. Your glucogenic patients have a tendency to gall bladder disease accompanied by gall stones. This results from their excess consumption of carbohydrate relative to fat. Glutamine supplementation will help liquefy the gall stones and increase the flow of bile acids through the gall bladder. - 4 - Switch your attention now to the ketogenic column of your QRG. Oxygenic K is the shining star at the top of the list. Look at the list of Oxygenic K ingredients with the same questions in mind that you asked about Oxy G -- why are these nutrients here, and why are only these nutrients here? You will find all the amino acids, vitamins, minerals, and trace minerals to enhance glucogenic metabolism and absolutely nothing that will further depress glucogenic metabolism. Every nutrient that is in Oxygenic K will increase the oxidation activity of you ketogenic patient and elevate carbon dioxide levels and decrease the serum pH. Again -- you have here specificity that can be obtained nowhere but from NUTRI-SPEC. Looking further down the list of ketogenic supplements you see tyrosine, phenylalanine, and methionine. Since these are three amino acids which also appeared on the glucogenic list you may be asking the obvious question -- how can the same amino acid supplements be beneficial for patients with totally opposite body chemistries? Here is the answer. It is true that tyrosine and phenylalanine are ketogenic amino acids and are therefore of critical importance for your glucogenic patients. But -- that is not the only role that tyrosine and phenylalanine play in the body. One other important metabolic pathway they participate in is as precursors to one of the important steps in the Krebs citric acid cycle. (For those of you who like to punish yourself with biochemistry -- it is the fumeric acid step at which these amino acids enter the citric acid cycle.) When I first started testing these amino acids clinically I had no way of knowing whether their major metabolic activity would be anti-glucogenic or anti-ketogenic. Here was a case where we got lucky. It appears that these amino acids push glucogenic patients in a ketogenic direction and push ketogenic patients in a glucogenic direction. It did not have to work out that way -- and I had no reasonable expectation that it would. But it did. This is particularly delightful news for us as NUTRI-SPEC practitioners because these amino acids can be so effective in giving a boost to our patients symptomatically. As with your glucogenic patients the tyrosine and phenylalanine can be used for ketogenic symptoms of allergies, depression, and fatigue. Again, however, we must be careful not to give these amino acids to our ketogenic patients if there is any strong sympathetic tendency. Methionine is also beneficial for the liver of your ketogenic patient. Methionine assists in detoxification. It facilitates liver function and increases the production of - 5 - lecithin in the liver. All of these are highly beneficial for your ketogenic patients who either suffer from allergies or have high cholesterol. Just be careful not to use methionine on ketogenic patients if they have low surface tension indicating a dysaerobic tendency. Finally on your list of anti-ketogenic supplements is the amino acid histidine. This is another supplement that we covered in great detail in the October Newsletter which you really should review. Histidine's use in your ketogenic patients is important in those patients who suffer from allergies or rheumatoid arthritis or anemia or nausea (particularly nausea of pregnancy) or GI ulcers or any auto immune disease. Histidine is so perfectly compatible with the ketogenic imbalance because it is the major amino acid which enters the Krebs cycle in which these patients are deficient. For that reason there is already some histidine in your Oxy K -- but additional supplementation is beneficial for many of these patients. Let's take one more look at your glucogenic/ketogenic Sugar Babies. Sugar handling stress is the very core of this particular metabolic control system. Most of the physical/ mental/emotional symptoms found in these patients are the result of either high or low blood and brain sugar, or, the body's response to dietary carbohydrate. Look at page 3 of your QRG. Under abnormal tests you find glucose; and next to glucose in the glucogenic column you find a huge word, "NEVER." Just as a midget cannot be tall and an orange cannot be blue -- a glucogenic patient, (by definition) cannot be diabetic. This has been a point of confusion for many of you because very often you find diabetic patients who test as glucogenic. The reason for this is almost invariably because insulin and the other diabetic medications push a person's chemistry in the glucogenic direction. Never treat a diabetic as glucogenic! This is an appropriate time to give you a quick summary of diabetes. All diabetic patients are ketogenic and/or sympathetic. That is why both your Oxygenic K and your Complex S are loaded with both chromium polynicotinate and BMOV Vanadium, two trace minerals which have an amazing ability to lower elevated blood sugar. Should you make the mistake of treating a diabetic as glucogenic (or parasympathetic) you can expect disastrous consequences. What has happened in your ketogenic patients that make them susceptible to diabetes? Your ketogenic patients are insulin resistant. These are your classic adult onset, - 6 - non-insulin dependent diabetics. Many of your ketogenic diabetic patients were actually hypoglcyemic (either parasympathetic or perhaps glucogenic) early in life. They have gone through a progression from hypoglycemia to a state of disinsulinsim to a state of insulin resistance and, if allowed to progress, to diabetes. There is no lack of insulin in these diabetic patients. In actuality, they have a life-long history of over-secreting insulin in response to excess carbohydrate intake. In early years this excess insulin output pushes the blood sugar lower and they suffer hypoglycemia. As the years pass the response to insulin becomes erratic -- thus a state of disinsulinism when blood sugar levels can be either very high or very low. Eventually the patient becomes more and more resistant to insulin. In other words, the patient still puts out tremendous amounts of insulin in response to dietary carbohydrate, but the body tissues are less sensitive to insulin so the insulin is ineffective at pulling the sugar out of the blood. Your ketogenic patients have symptoms associated with the high blood sugar, but even more symptoms are associated with the high levels of insulin. High insulin is implicated as a causative factor in high blood pressure and in many forms of premature aging, and in many hormone imbalances. Whether you are dealing with the classic hypoglycemic crisis typical of your glucogenic patients or the insulin resistance of your ketogenic patients -- you will find that the only way to achieve glycemic control in these patients is with you NUTRI-SPEC testing and supplementation protocol. No one else can come close to the value you, as a NUTRI-SPEC practitioner, offer these patients. Sincerely, Guy R. Schenker, D.C. P.S: Mighty Mins are here! Mighty Mins are here! MIGHTY MINS ARE HERE! Mighty Mins? Yes, Mighty Mins! Our chewable supplement for children is finally available. It is the child's equivalent of Oxygenic B -- and every child you know from 6 months through puberty must take this supplement (whether you are doing NUTRI-SPEC testing on them or not). Call us today for information and to place your order.