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Volume 11 Number 12

Guy R. Schenker, D.C.
December, 2000

Dear Doctor, 

How would your body respond if you were subjected to the
overwhelming stress of burn trauma?  Hormonally, you would be
devastated.  Those hormones that promote health and longevity would
take a precipitous plunge -- thyroid hormone levels crash,
progesterone plunges, and testosterone all but disappears.  Meanwhile,
your catecholamine levels skyrocket, and cortisol surges, as does the
other stress hormone, estrogen.  

What would be your body's response to surgical trauma?  Again,
thyroid, progesterone, and testosterone crash while the stress
hormones, including catecholamines, cortisol, and estrogen, are
produced in excess. 

What would be your hormonal response to the stress of alcoholism, or
starvation, or to extreme cold exposure, or to a severe infection?  You
guessed it -- healthy hormone levels tumble, while catecholamines,
cortisol, and estrogen rise to dangerously unsustainable levels.  Check
the following references:

Yu, Effect of endotoxin on hormonal responses, Am J Vet Res. Feb,

Doleck, Endocrine changes after burn trauma, Keio J Med, Sep, 1989.

Dennhardt, Patterns of endocrine secretions during sepsis, Prog Clin
Biol Res, 1989.

Keck, Alcohol and endocrinologic homeostasis, Z Gastroenterol, Oct,
1988.  (German)

Vagenakis, Diversion of peripheral thyroxin metabolism from
activating to inactivating pathways during complete fasting, J Clin
Endocrine Metab, 1975.

Elliot, Sustained depression of the resting metabolic rate after massive
weight loss, Am J Clin Nutri, 1989.

The point I am making as clear as I possibly can is that 


in that it is used in defense against extreme stressors.  

Like all stress hormones, estrogen is essential for dealing with a crisis,
but is damaging when it is present in excess quantity, or present out of
time with need.  And that is our problem -- you, I, and most all our
patients, are producing stress hormones far in excess of what should
be produced in response to activities of daily living.  Some of us
(particularly those who are anaerobic, ketogenic, or parasympathetic)
respond to stress with excess cortisol.  Some of us (particularly those
who are dysaerobic, glucogenic, or sympathetic) over-react to stress
with excess catecholamine production.  Some of us respond to stress
with both too much cortisol and too much catecholamine production. 
And, nearly all of us respond to stress with excess estrogen.  

It is common knowledge that excess catecholamines and cortisol are
associated with cardiovascular disease, with hypertension, with
decreased immune function, with predisposition to cancer -- in short,
with all the killer diseases.  Largely unknown, however (thanks to very
effective propaganda by the pharmaceutical industry), estrogen
contributes every bit as much to the deadly diseases to which most of
us eventually succumb, and, it contributes to an amazing diversity of
"ordinary" miseries from which most of your patients suffer.  Consider
carefully this list of conditions associated with excess estrogen:

- Estrogen causes seizures.
- Estrogen causes allergies.
- Estrogen causes cancer (not just the obvious breast cancer, uterine
cancer and cervical cancer, but many forms of cancer, in both men and
- Estrogen causes anxiety.
- Estrogen causes cystic breast disease.
- Estrogen causes uterine fibroids.
- Estrogen causes endometriosis.
- Estrogen causes dysmenorrhea.
- Estrogen causes premenstrual syndrome.
- Estrogen causes prostate disease.
- Estrogen causes gall stones and gall bladder disease.
- Estrogen causes fluid retention.
- Estrogen causes weight gain.
- Estrogen depresses thyroid function.
- Estrogen causes osteoporosis (and you will learn how the deceitful
lie that estrogen protects against osteoporosis was fabricated on a
- Estrogen causes hypoglycemia and associated food cravings.
- Estrogen increases the risk of heart attacks and strokes.

Do you see any symptoms on that list that are common among your
patients?  Do you see any symptoms on that list that you would like to
be able to effectively control or eliminate altogether?  Certainly you
do.  Most of these symptoms or conditions can be benefited (often
dramatically) with NUTRI-SPEC but -- the vast majority of your
patients with these symptoms who do not completely respond to
NUTRI-SPEC are generally suffering the effects of excess estrogen.  

Let us focus on these symptoms one by one and see how they relate to
estrogen stress, and particularly how you can use NUTRI-SPEC to
help patients suffering from these conditions.  

Look at the second symptom on the list ...                        


I'll bet you didn't know that.  I'll bet you won't find one in a hundred or
maybe not even one in a thousand doctors who knows that.  Why
doesn't anyone know that simple fact?  Simply because there are a lot
of very powerful influences that don't want you to know that.                 

How many patients do you have that walk around with a head full of
boogies virtually all the time?  Most of these patients (including most
of the men) are suffering from estrogen stress.  Sadly, many of these
patients who are females are either on birth control pills or hormone
replacement therapy.  Perhaps you have done NUTRI-SPEC on these
patients and achieved some success.  With the proper
supplementation, and the proper diet (including the prostaglandin
dietary recommendations) these patients will improve markedly.   But,
how many of these patients, even under the best NUTRI-SPEC care,
reach a plateau beyond which further improvement seems impossible? 
Excess estrogen is the only barrier preventing you from 100% success
with these patients.  

Below are just a few of several hundred references demonstrating the
fact that estrogen potentiates the activity of histamine.  By that
mechanism, and by several others involving immunoglobulins,
estrogen exacerbates symptoms of allergies and asthma.

1. Prudhomme A. Influence of Female Sex Hormones on Asthma. 
Rev Pneumol Clin 1999 Oct;55(5):296-300.

This study showed that sex hormones have a clear effect on 30-40 
percent of asthmatic women.  It also showed that hormone 
replacement therapy has an unfavorable effect on the incidence of 
asthma in peri and post-menopausal women.

     So, in addition to your NUTRI-SPEC metabolic imbalances,
     prostaglandin imbalance, on all your asthmatic patients you must 
     also consider estrogen stress.  Estrogen will be exacerbating the 
     asthma directly, and also indirectly by virtue of being a causative 
     factor in virtually all your NUTRI-SPEC metabolic imbalances.  

2. Hamano N, et al.  Effect of Female Hormones on the Blood
Production of IL-4 and IL-13 from Peripheral Blood Mononuclear
Cells.  Acta  Otolaryngol Suppl 1998; 537:27-31.

This study demonstrated that estrogen aggravates nasal allergy
symptoms by increasing immunoglobulin E synthesis and inducing
selective eosinophil infiltrations.

     One thing we have noticed in the hundreds of problem cases we
     review for you each year is the high percentage of women either on 
     birth control pills or hormone replacement therapy whose allergic 
     symptoms stubbornly refuse to respond, and who are taking Claritin 
     or some other antihistamine --  a drug to reverse the side effects of 
     another drug -- needed only because of allergies caused by

3. Derimanof G: Oppenheimer J.  Exacerbation of Premenstrual
Asthma Caused by an Oral Contraceptive.  Ann Allergy Asthma
Immunol 1998 Sep;81(3):243-6.

This study is one of many showing that exogenous estrogen and/or
contraceptive pills produce an exacerbation of asthma.

4. Wjst M, Dold S.  Is Asthma an Endocrine Disease?  Pediatr Allergy
Immunol 1997 Nov;8(4):200-4. 

This study presented evidence that the increasing incidence of asthma
in children is due to the mother's oral contraceptive use prior to

This is stunning!  There has been an inexplicable increase in
childhood asthma in the last several decades.  Now we see that one
(there are probably several others) major cause of this asthma
epidemic is children unfortunate enough to be born to women who
didn't know any better than to use birth control pills prior to choosing
to be pregnant.  You can bet the pharmaceutical companies will spare
no expense in suppressing this study and others like it.  

5. Hamano N, et al.  Expression of Histamine Receptors in Nasal
Epithelial Cells and Endothelial Cells-The Effects of Sex Hormones. 
Int Arch Allergy Immunol 1998 Mar;115(3):220-7.

In this study the exacerbation of histamine activity by estrogen was
demonstrated.  Definitive evidence was given that estrogen is the
primary cause for the preponderance of allergic rhinitis after puberty
in females, and the further exacerbation of these allergic symptoms
during pregnancy.

 There was certainly nothing wishy washy about this study.  It did    
 not just implicate estrogen as a causative factor in allergies, it 
 unequivocally  stated that estrogen is the primary cause of allergies  
 in females, and the sole reason for an exacerbation of allergies in  
 women during pregnancy.  

Now that you are acquiring a thorough knowledge of the devastating
effects of estrogen, how do you use this information clinically?  You
simply must convince all your women on hormone replacement
therapy to decrease if not completely delete the estrogen.  The first
step is, obviously, to convince each woman that she must get off the
estrogen.  To do that, present her with the list of estrogen-related
conditions and symptoms listed above.  Emphasize in each individual
woman's case those symptoms that she already has, or that are most
unappealing to her.  (It is amazing how many women are more easily
convinced to get off estrogen by the fact that it causes weight gain
than by the fact that it causes cancer.)  

Along with assuring the woman that she will avoid all those symptoms
and conditions by getting off the estrogen as soon as possible, you
must also convince her that there is no risk in getting off the estrogen. 
The next issue or two of this Letter will complete the case against
estrogen including giving you all the references from the literature you
need to present a convincing case that estrogen does not protect
against heart disease and above all, does not prevent (and actually
contributes to) osteoporosis.  

Once you have the woman convinced that most if not all of her
symptoms are caused by or at least exacerbated by estrogen, and, that
many more miserable symptoms are certain to come her way in the
future if she stays on the estrogen, then you must put her on the proper
plan for getting off the drug.  

Under no circumstances should she quit the estrogen cold turkey.  The
withdrawal must be gradual enough that there is no radical upset to
her hormonal balance.  The procedure is really quite simple.  She
continues on her present dose of estrogen but simply deletes one day
of the week -- Monday for instance.  After one or two weeks of taking
the estrogen six days a week she deletes a second day -- Friday.  After
taking the estrogen five days weekly for two weeks she deletes
Wednesday, so that now she is only taking estrogen four days a week.  
After a week or two at that level she will start to take the estrogen on
Monday, Wednesday and Friday.  After a couple weeks at that level
she will reduce it to taking it only Monday and Friday.  And after a
couple weeks at that level she will reduce it to one day a week, and
then eventually she can delete it altogether.  

Along the way if the woman begins to experience hot flashes of
frequency and intensity that are more than just slightly annoying, then
she should stop at that level of estrogen intake until things stabilize,
which could be an extra week or two or much longer.  If the hot
flashes reach what could be called an extreme level, and/or she
experiences some vaginal dryness, then she should go back a step --
add back one more dose of estrogen each week until things stabilize. 
Then, after stabilization, resume the gradual withdrawal again to
whatever extent is possible.  

There is only one other consideration in this estrogen phase out
procedure and that is the possibility that you can supplement with
other hormones and hormone precursors to physiologically help the
woman attain hormone balance.  There are combinations of natural
progesterone (not Provera), DHEA, and pregnenolone that can be very
beneficial adjuncts to the phase out of estrogen (and at the same time
very valuable to help maintain NUTRI-SPEC metabolic balance in
these patients that are hormonally challenged).  We will cover the
protocol for the use of these supportive hormones next month. 

Guy R. Schenker, D.C.


Nutri-Spec Letters