From: Guy R. Schenker, D.C. August, 1997 Dear Doctor, Every patient that comes through your door is likely to have an anaerobic/dysaerobic component to their major symptomatic complaint. Why is it that such a high percentage of your patients will only be restored to health when you have restored anaerobic/dysaerobic balance? Because ... MAINTAINING ANAEROBIC/DYSAEROBIC BALANCE IS THE ESSENCE OF LIFE ITSELF. Recall from last month's Letter that this balance system is all about two primary biological functions: - producing energy with oxygen - maintaining the selective permeability of tissue membranes Is it any wonder that virtually any symptom or complaint in any one of your patients can be associated with this fundamental metabolic balance system? High cholesterol and cardiovascular disease almost always have an anaerobic or dysaerobic component. Allergies almost always are associated with an anaerobic or dysaerobic tendency. Gastro intestinal function depends upon anaerobic/dysaerobic balance. Chronic fatigue, arthritis, and emotional problems are all frequent manifestations of anaerobic/dysaerobic balance. If one of your patients is suffering from one of these or any of dozens of other maladies associated with an anaerobic or a dysaerobic imbalance -- nothing you do for them will have a permanent therapeutic effect until you have corrected the cause of their affliction. Only by restoring normal oxidative energy production and restoring normal membrane function will your patient enjoy any lasting benefits. We reviewed for you last month the simple procedure using your Quick Reference Guide (QRG) to determine whether each of your patients has this all-important fundamental imbalance in literally less than ten seconds. When your QRG analysis turns - 2 - up an anaerobic/dysaerobic problem in a patient your QRG goes on to tell you exactly what you must do to restore balance in that particular patient. Your NUTRI-SPEC treatment protocol for your anaerobic/dysaerobic patients includes a list of supplements with incredible biological activity. Let us look briefly at these amazing supplements. All your anaerobic/dysaerobic patients will be given Oxygenic B (of course) along with either Oxygenic A and A+ or Oxygenic D and D+. Just what do these supplements do, and how do they do it? Think again about your goal with these patients. You want to restore normal oxidative energy production and normal membrane permeability. In the process of properly re-polarizing the membranes you will restore normal acid/alkaline balance both within the tissues and systemically. Every ingredient in Oxygenic A and Oxygenic D is designed to correct either a cause or an effect of abnormal oxidation, membrane dysfunction, or abnormal pH. Every ingredient in each of these products is there for a specific purpose. Furthermore, each ingredient is there in the exact quantity and in the exact proportion to other nutrients to facilitate the rebalancing of your anaerobic/ dysaerobic patients -- with certainty that no other NUTRI-SPEC imbalances will be created in the process. If you take a quick look at your Oxygenic A label, what are some of the goodies you will find? The first thing that should jump out at you is the amazing glutathione. Combining the quantity of glutathione in Oxygenic A with the dosage that all your patients receive in Oxygenic B gives a powerful therapeutic dosage of this phenomenal nutrient. I could feed you page after page from the scientific literature on the incredible biological effects of glutathione. Let me at least give you the following list as a general summary: - extracellular glutathione protects cells of diverse tissues against oxidation injury. - within the cells glutathione is the dominant sulfur containing biological and functions directly or indirectly as an antioxidant. - it is the major transport form of the amino acid cysteine. - glutathione participates in the synthesis of proteins and DNA precursors. - glutathione functions as a co-factor for many diverse enzymes. - 3 - - glutathione is important in the initiation and progression of white blood cell activation, and thus is essential to the immune system. - gluatathione is critical for the function of natural killer cells and for lymphocyte-mediated cyto-toxicity. As such, it is a powerful anti-tumor agent and is an important part of therapy for AIDS patients. - It is important in the prevention and treatment of liver and blood disorders. - It is a detoxifyer of heavy metals and drugs. - It plays an important role in slowing the aging process. - It has been used effectively in the treatment of allergies, cataracts, diabetes, hypoglycemia and arthritis. - It is more effective than Vitamin C as a reducing agent for enhancing the utilization of iron, cysteine and cystine. - When given orally it is more effective than super oxide dismutase in protecting cells from oxidation reactions. - It will ameliorate the harmful side effects of high dose radiation and chemotherapy. - It accelerates respiration in the brain. - It protects against damage from cigarette smoke and alcohol. Having read this list, ask yourself, where are you going to find this invaluable nutrient to offer your patients? For the most part it can only be had as a speciality product at great expense. Yet here you have it in a clinically significant dosage if 40 milligrams just in the Oxygenic B that you give every one of your patients. You find an additional 50 milligrams in your Oxygenic A. No where else, and I mean no where else will you find glutathione included in meaningful quantities in other companies' products. This is an appropriate place to caution you about a deceitful labeling practice very common in this industry. I hold in my hands the list of ingredients from the number one product produced by one of the country's most famous nutrition gurus. He hypes this product with every rah-rah superlative imaginable, knowing full well that people are going to be easily snookered by the fact that he, with his world famous reputation, personally designed this product to be uniquely superior to anything else on the market. The product is, as - 4 - you may well imagine, pure garbage. It contains ultra mega doses of all the cheapest health food store quality nutrients and then dresses up the label with lots if impressive sounding "antioxidants," including no less than 1600 units of glutathione. 1600 units? 1600 micro grams, that is. This is a perfect example of the all too common lack of ethics that pervades this industry. NUTRI-SPEC stands as an oasis in a desert of deception -- standing for truth and integrity in clinical practice. But anyway -- back to glutathione. No where but in Oxygenic B can you find glutathione in significant quantities in a multiple-type product. No where but in Oxygenic A can you find glutathione with companion nutrients that potentiate its powerful biological effect. Next, you will notice on your list of Oxygenic A ingredients the sulfur-containing amino acids methionine and cysteine. The sulfhydril groups in these amino acids have a powerful impact on all aspects of the anaerobic imbalance -- the oxidative component of the problem, the abnormal membrane permeability, and the tissue pH. You will also notice that the minerals and trace minerals in Oxygenic A are mostly in aspartate form. The aspartic acid (as well as the glutamic acid) has a strong anti-anaerobic effect as we learn from Rivici (on whose paradigm your anaerobic/dysaerobic balance is based). From the work of the famous German oncologist Hans Neiper we know that when you combine a mineral with aspartic acid you get some very nice biological effects. The aspartate functions as an effective carrier of that mineral -- taking it directly to the portion of the cell or the cell membrane where it exercises its biological activity. Calcium aspartate is particularly beneficial for bone re-mineralization and for transport of calcium to within the cell where it has its biological activity. Calcium aspartate also helps repair damage to cartilage tissue. Furthermore, calcium aspartate protects membranes from immune aggression, for example, in the treatment of allergies. Aspartic acid has also been demonstrated to have a potent effect in the treatment of chronic fatigue syndrome. Of course, with the nutritional specificity at your disposal with your NUTRI-SPEC system you know that the people with chronic fatigue who respond well to aspartates are those patients who have an anaerobic or ketogenic component to their fatigue. Magnesium aspartate is particularly effective in feeding the heart and in maintaining the integrity of the vascular system. Magnesium aspartate is a particularly effective form - 5 - of magnesium in magnesium's role of lowering cholesterol. The trace minerals copper and manganese when put in aspartate form have their anti-anaerobic biological activity potentiated. Selenium and vanadium are two other essential trace minerals to your anaerobic patients. The selenium is in the form selenomethionine, a compound that we have discussed in past Letters. The vanadium is in BMOV form which is the most biologically active form of vanadium, and which has a tremendous impact on carbohydrate and fat metabolism. (You will note that you have BMOV vanadium in much higher therapeutic doses in both your Oxygenic K and your Complex S because of its beneficial effect on your diabetic patients.) I think we've said enough about the potency of Oxygenic A in balancing your anaerobic patients. Let us now take a quick cruise through the label of Oxygenic D. Take note of the glucosamine. Glucosamine is well known for its favorable impact on connective tissue problems, both in controlling inflammation and in maintaining the integrity of joint cartilage. Rivici demonstrated there is also a metabolic affect of glucosamine that helps regulate sugar metabolism, and which is associated with hormone production. With these metabolic effects in mind you can see that all your dysaerobic patients benefit tremendously from glucosamine. Many of your dysaerobic patients do have connective tissue problems and for them the glucosamine does double duty. Near the top of your Oxy D label you will find listed the five anti-dysaerobic amino acids -- histidine, lysine, arginine, glycine and glutamine. Arginine is interesting in its ability to antagonize cholesterol and reduce atherosclerosis. Another important biological activity of arginine is its role in potentiating insulin. (This is why you also find a large dose of arginine in your Complex S.) Arginine, along with lycine and glycine, are known as alkaline amino acids, which were shown by Rivici to have a significant anti-dysaerobic effect on membrane permeability and membrane polarity. Glycine is particularly important in energy metabolism in muscle tissue. Lysine and arginine have an anabolic effect on collagen. You can see why these two amino acids (plus glucosamine) in your Oxy D are so effective on rheumatoid arthritis, commonly a dysaerobic condition. Histidine and glutamine are not only part of your Oxy D but are available for your use as separate supplements for your dysaerobic patients. We will give a detailed description of the use of amino acids for anaerobic/dysaerobic imbalances in next month's Letter. - 6 - What other goodies do you find in Oxy D? In addition to all the anti-dysaerobic vitamins, minerals, and trace minerals you find the powerful antioxidants quercetin and rutin. You must certainly be aware that proanthocyanidins from grape pips and pine bark are all the rage these days because of their "extraordinary" antioxidant activity. Grape pips and pine bark are members of the bioflavenoid family, as are quercetin and rutin. I have yet to see any objective evidence that the pine bark and grape pip extracts are any more potent or any more biologically active than the bioflavenoids that you have in Oxy D. I suspect that the pine bark and grape pips lent themselves well to an appealing sales pitch and thereby came to be heavily hyped by the natural food industry. These newcomers to the recognized bioflavenoid group cannot begin to match the quantity of scientific literature in support of the powerful antioxidant effects of quercetin and rutin. If you look at the molecular structure of the pine bark and grape pips extracts they are so similar to quercetin and rutin that it is difficult to imagine that they have any properties that distinguish them as superior in any way. These Johnney-come- latelies are over-hyped and over-priced. You are getting the same extraordinary biological activity from the quercetin and rutin in your Oxy D and other NUTRI-SPEC products. Oxy D gives you the anti-dysaerobic trace minerals zinc, molybdenum and chromium. The chromium is as polynicotinate -- the form well known for its effect on balancing sugar and fat metabolism, and on stablizing blood sugar levels. I could probably devote an entire Letter to every single ingredient of Oxy A and Oxy D -- but I am sure you already get the big idea. No where else can you obtain nutrients synergistically combined for such a specific impact on energy metabolism, membrane permeability and pH balance. Sincerely, Guy R. Schenker, D.C. P.S.: We are all being inundated with sales literature hyping PYRUVATE supplementation. I have prepared a critique on Pyruvate which we will send with your next order -- just ask for it.