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Volume 10 Number 7

Guy R. Schenker, D.C.
July, 1999

Dear Doctor,

     What can you do that no other doctor can do?  You can 
take any total stranger and within minutes begin to 
restore that person's ability to perform the following 
essential functions:

a.  Maintain glycemic control
b.  Maintain normal oxidative metabolism
c.  Maintain ideal pH
d.  Maintain ideal concentrations of electrolytes and       
    biologically active water

     How important are these four essential functions?  
They are the whole story.  If you are talking about health 
vs. disease -- they are the difference between living 
stronger-longer and being sicker-quicker.  Yet while these 
functions are virtually the essence of life, you (and only 
you as a NUTRI-SPEC practitioner) have the power of 
control over them.

     And where do you derive your power to control these 
vital functions?  From your objective system of analysis 
-- a system which allows you to appraise in just minutes 
any individual's status with respect to the metabolic 
control systems which govern those four essential 

     You refer to these metabolic control systems as the 
NUTRI-SPEC fundamental balances.  There are 5 of these 
fundamental control systems.  You have come to learn that 
these control systems are the engines that drive body and 
mind.  When these engines are working efficiently one can 
move through life with strength and vitality.  When one or 
more of these control systems loses efficiency, body and 
mind simply cannot perform at their best.

     Yes, you have the power of control -- and objectivity 
is intrinsic to your power.  But while an objective means 
to analyze the 5 fundamental metabolic control systems
                          - 2 -

does give you the ability to favorably influence the four 
essential functions, does that mean that your job is an 
easy one?  Usually not.  You are often working against 
tremendous odds.  And your most likely adversary is the 
person you are trying to help.  That brings us to a 
discussion of the Glucogenic/Ketogenic control system.

     Of all the five NUTRI-SPEC imbalances, glucogenic/
ketogenic is the one that is the most self-inflicted.  In 
other words, it is the imbalance that is most associated 
with the miserably inadequate diet and sedentary lifestyle 
that typifies most of your patients.  It is thus the 
imbalance that is most totally responsive to diet and 
exercise, and thus the one that can be most easily 
sabotaged by your patients' self destructive lifestyle 
choices.  Of the four essential functions listed above, 
the two that are most intimately and directly associated 
with glucogenic/ketogenic imbalances are the maintenance 
of glycemic control and the maintenance of ideal pH, 
(particularly the systemic pH).

     Is your glucogenic/ketogenic patient your ally or 
your adversary in achieving metabolic balance and 
restoring essential function?  Think of it this way.  The 
average American consumes 100 pounds of sucrose each year.  
That amounts to an astounding 20% of our caloric intake in 
the form of refined sugar.  That does not even include the 
additional "natural" sugars that are additionally consumed 
in the forms of juices and fruit.

     Now, if your average person consumes that much sugar, 
and if the loss of glucogenic/ketogenic control is largely 
associated with loss of glycemic control -- you can well 
imagine that your typical glucogenic/ketogenic patient 
consumes sickening (literally) quantities of sugar.

     Furthermore, in people that have an inborn tendency 
to either a glucogenic or ketogenic predominance in their 
metabolism, even the "ordinary" grotesque sugar intake of 
the average person is enough to push them into a 
devastating state of imbalance.

     What are the clinical effects of glucogenic/
ketogenic imbalance?  Symptomatically speaking, your most 
common major complaints among these people would be:

- fatigue
- overweight or underweight
- hypoglycemia or diabetes (and all sequelae)
- anxiety, depression and mood swings
- premature aging
                          - 3 -

     At the core of this imbalance is a patient's 
inability to access the energy production pathway that is 
apropos of the moment.  Your glucogenic patient is 
deficient in oxidative energy metabolism from fats and 
ketogenic amino acids via the beta hydroxy butyric acid 
cycle.  At the same time that patient has an over- 
dependence on glucogenic energy production associated with 
metabolism of carbohydrates and glucogenic amino acids, 
largely via the citric acid cycle.

     Conversely, your ketogenic patients are deficient in 
glucogenic energy production, and have an over-dependence 
on ketogenic metabolism.

     You can easily imagine how glucogenic/ketogenic 
patients are continuously struggling with glycemic 
control.  Their blood sugar and brain sugar levels tend to 
be quite erratic.  Then, having lost the essential 
function of glycemic control, the sky is the limit as far 
as both physical and mental symptoms are concerned.

     While much of the fatigue, weight problems, high and 
low blood sugar and the emotional symptoms associated with 
glucogenic/ketogenic imbalances directly result from the 
erratic sugar levels and the hormones associated with 
these sugar levels (such as excess catacholamines in your 
glucogenic patients, and excess cortisol as well as 
insulin resistance in your ketogenic patients), there is 
another component of this imbalance that leads directly to 
symptoms.  There is a loss of pH control at the systemic 
level associated with glucogenic/ketogenic imbalances.

     Largely associated with the production of carbon 
dioxide as a metabolic end product, we find that 
glucogenic patients tend to be somewhat acid at the 
systemic level.  Ketogenic patients tend to be alkaline.  
Watson (upon whose work our glucogenic/ketogenic paradigm 
is based) showed that aberrations in serum pH were more 
directly correlated with patients' symptoms than any other 
quantifiable factor.  Foods and nutrition supplements 
which increased the systemic pH were immediately 
beneficial for glucogenic patients and devastating for 
ketogenic patients.  Acidifying foods and supplements had 
the reverse effect.

     With the deficiencies in oxidative energy metabolism, 
the inefficiencies in drawing upon appropriate energy
reserves, the abnormal carbon dioxide and pH levels and 
the virtually unlimited chain reaction of symptoms and 
conditions that can be associated with glucogenic/

                          - 4 -

ketogenic imbalances, how can you get an objective handle 
on this balance system?  In other words, how can you
quantify this imbalance as a means to analyze each 
patient?  Your QRG does the job quite nicely.

     Since your adjusted saliva pH is directly influenced 
by C02 levels, and since a patient's respiratory rate, 
breath hold time and pulse are all influenced by pH 
changes, your QRG 4-Point Quick-Scan enables you to 
determine in just seconds whether your patient is likely 
to have a glucogenic/ketogenic imbalance.

     You see, since your glucogenic and ketogenic patients 
must make continuous compensation to their abnormal carbon 
dioxide and pH levels, there are no absolute 
generalizations that can be made with respect to their 
test results.  Instead, it is necessary to define 
glucogenic/ketogenic imbalances in terms of abnormal 
ratios of the saliva pH, breath hold, respiratory rate and 
pulses.  All these ratios are neatly worked into one 
concise chart in your QRG analysis.

     This is an appropriate time to alert you to one 
further refinement of your QRG analysis for glucogenic/
ketogenic imbalances.  The additional improvement in your 
analysis relates to your analysis of children.  The note 
you want to make on your QRG is that for a child make the 
following two allowances:

1.  If the child's breath hold is less than 40 seconds,     
    then count it as 40 seconds.

2.  Instead of using the child's P4 in the analysis, use    

     These two changes will make your glucogenic/ketogenic 
analysis of children much more reliable.  This is 
essential because this imbalance is extremely common in

     We have alluded many times in the past to the 
tremendous benefit to be derived from doing NUTRI-SPEC on 
children.  Some of the most dramatic clinical responses in 
children are in those who are being treated as ADD or 
ADHD.  You have learned that many of these children are 
glucogenic with a powerful sympathetic compensatory 
response to their blood and brain sugar instability.  The 
resulting combination of crashing blood sugar and surging
catacholamines is what causes these children to bounce off 
the walls with no ability to maintain focus on either 
academics or rules of behavior.
                          - 5 -

     The quick response of ADHD children (or any children 
for that matter) to metabolic balancing with NUTRI-SPEC is 
sometimes astounding.  You will rarely experience anything 
more gratifying than turning a child's life around.

     Once you have determined a patient to be either 
glucogenic or ketogenic you need only turn to the 
appropriate page of your QRG for the specific 
supplementation needed.  Your Oxygenic G has all the amino 
acids, vitamins, minerals and trace minerals to push the 
patient out of an acid hypoglycemia into the ketogenic 
energy production pathways which are deficient.

     Your Oxygenic K contains all the amino acids, 
vitamins, minerals and trace minerals to push the patient 
out of alkaline insulin resistance into the efficient use 
of energy through glucogenic pathways.

     Your supplement selection page gives specific 
protocol for the use of many other supplements which will 
enhance the speed at which metabolic balance is restored, 
and also the speed at which symptoms respond.

     In summary, we would note that while your glucogenic 
and ketogenic imbalance represent opposite phases of a 
diphasic metabolic control system, they both have one 
thing in common ...

                  SUGAR HANDLING STRESS.

Quite simply -- some people succumb to a 100 pound annual 
sugar assault by getting stuck in a glucogenic rut.  
Others react to the overwhelming sugar load with a 
ketogenic metabolic response.

     This is the NUTRI-SPEC key concept of biological 
individuality displayed quite clearly.  The same metabolic 
stressor can result in the exact opposite metabolic 
response in two different people.

     Never lose sight of the fact that if your patient is 
glucogenic or ketogenic, the perfect supplement regimen 
can only take the patient so far if the relentless stress 
of the 100 pound sugar load is not removed.  That is to 
say that strict adherence to the NUTRI-SPEC Fundamental 
Diet is more important for patients of glucogenic/
ketogenic imbalance than any others.  (That is not to say 
that it is not absolutely essential for all your patients 
-- just that your glucogenic/ketogenic treatment regimen 
is 100% doomed to fail without strict dietary compliance.) 

                          - 6 -

Not only must sugar be deleted, but the proportion of 
carbohydrate in the diet is an essential consideration.

     For patients of these imbalances who are obese, you 
can decrease the carbohydrate percentage to far below the 
quantities called for by your NUTRI-SPEC Fundamental Diet.  
For your overweight glucogenic patients in particular, it 
can make all the difference in the world to put them on an 
extremely restricted carbohydrate diet, enough to push 
them into a state of ketosis and keep them there.

     Your obese ketogenic patients may follow the 
ketogenic dietary recommendations but also with aggressive 
carbohydrate restriction.  You will find that it requires 
a less stringent diet too keep these  patients in ketosis.

     When properly maintained on the NUTRI-SPEC 
Fundamental Diet with low carbohydrate emphasis (and 
accompanying increase in saturated fat and protein such 
that calories are not restricted) to enhance ketosis, the 
patient will not only see pounds melt away, but will see 
an immediate improvement in emotional status, energy 
levels and digestive efficiency.

     Even without special carbohydrate restriction, 
balancing any patient who suffers from a glucogenic or 
ketogenic tendency will ...



                            Guy R. Schenker, D.C.

P.S.:  One clinical manifestation of glucogenic/ketogenic
imbalances that we listed above was premature aging.  We 
listed it, then did not discuss it in the least.  That 
will be the subject of an upcoming Letter which will deal 
with the topic of GLYCATION.  While that discussion will 
take an entire Letter to cover, let me give you a quick 
preview of that coming attraction.  There is only one food 
that rivals polyunsaturated fatty acids in its devastating
capacity to accelerate the aging process.  What is that 
food?  The common sugar fructose which is the 
monosaccharide found in high concentrations in most fruit, 
and which constitutes 50% of the disaccharide sucrose.


Nutri-Spec Letters