From:
Guy R. Schenker, D.C.
July, 1997


Dear Doctor,

     Check out the following list of symptoms and conditions:

* High Cholesterol                 * High Cholesterol
* Allergies                        * Allergies
* High Blood Pressure              * Migraine Headaches
* Constipation                     * Colitis; Diarrhea
* Somnolence; Fatigue              * Insomnia; Fatigue
* Depression                       * Anxiety
* Osteo Arthritis                  * Rheumatoid Arthritis
* Tachycardia                      * Hypoglycemia
* Vertigo                          * Vertigo
* Itching                          * Itching
* Recurring Infections             * Recurring Infections

     Do you see anything in that list that you would like to 
be able to handle clinically?  Do you see anything about which 
you frequently hear your patients complaining?

     What you have  just seen is a list of the symptoms and 
conditions typically associated with ...

        ANAEROBIC AND DYSAEROBIC METABOLIC IMBALANCES.

If one of your patients complains of something from that list 
there is a far better than 50-50 chance that they have either 
an anaerobic (left column) or a dysaerobic (right column) 
imbalance.  Furthermore, if you give that patient the proper 
NUTRI-SPEC regimen to restore metabolic balance these symptoms 
and conditions will consistently respond well, and often 
respond dramatically.

     How difficult is it to find and treat this vitally 
important metabolic balance system?  It is as simple as 
following the protocol on page 2 of your Quick Reference Guide 
(QRG).

                            - 2 -


     The first thing you will notice at the top of the 
Anaerobic/Dysaerobic page of your QRG (and at the top of each 
page of your QRG) is a list of four tests designated as a 
"Quick-Scan."  These four most primary tests to consider on 
each of your patients for your Anaerobic/Dysaerobic analysis 
are:  the urine surface tension, the urine pH, the urine 
specific gravity, and the adjusted saliva pH.

     As you should know by now, the trick to doing your QRG 
analysis in just a minute or two is to learn to pull these 
four numbers off your patient's test results form and carry 
them to the QRG as a group.  It then takes no more than five 
or ten seconds to see if those four tests are a match with 
either the anaerobic or dysaerobic column of the QRG.

     The QRG then instructs you that if you do not have the 
surface tension plus at least two others of these four tests 
matching one of the columns, then you need look no further.  
Just turn the page and consider your next imbalance.

     If you do have the surface tension plus at least two 
others matching either the anaerobic or dysaerobic column then 
you need to continue to consider the other few tests to 
complete your analysis of this imbalance.

     Why do these four tests relate specifically to Anaerobic/ 
Dysaerobic metabolism?  To answer that, you must understand 
what an Anaerobic/Dysaerobic imbalance is all about.

     Our NUTRI-SPEC Anaerobic/Dysaerobic balance system is 
based upon the paradigm developed by Emmanuel Rivici.  Dr. 
Rivici was unique in being both a world class molecular 
biologist and a world class clinician.  From studying Rivici's 
work we know that Anaerobic/Dysaerobic problems can be thought 
of in two ways:

- an imbalance in oxygen metabolism

- an imbalance in lipid metabolism

     Furthermore, Rivici has shown that oxidative metabolism 
and lipid metabolism are functionally related in two ways:

- to produce energy with oxygen efficiently

- to control membrane permeability

     Are we talking about anything important here?  When we 
talk about oxidative energy production and the selective 
permeability of biological membranes we are talking about the
essence of life itself.  That is why ...
                            - 3 -


      ANAEROBIC/DYSAEROBIC BALANCE IS THE MOST PERVASIVE
             OF YOUR FIVE NUTRI-SPEC IMBALANCES.

In other words, Anaerobic/Dysaerobic forces play a part in 
virtually everything that happens in the human body.  That is 
also why virtually any symptom or condition you can name is 
likely to have an anaerobic or a dysaerobic component.

     What exactly has gone wrong in a patient who shows you an 
anaerobic or dysaerobic imbalance?  Looking at lipid 
metabolism and simplifying just a bit, let us say there are 
two classes of biologically active lipids -- sterols and fatty 
acids.  Each of these classes of lipids plays an important 
role in both oxidative energy metabolism and in membrane 
function.

     Let us consider oxidative energy production first.  Your 
anaerobic patient has insufficient fatty acid activity and 
excess sterol activity.  This lipid imbalance affects 
oxidative energy metabolism such that your anaerobic patient 
is just what the name implies -- producing energy without 
oxygen.  This patient does not produce energy with oxygen in 
sufficient quantity.  Instead, there is an over dependence on 
fermentative anaerobic energy metabolism (anaerobic 
glycolysis) rather than the efficient production of energy 
with oxygen.

     Your dysaerobic patient has excess fatty acid activity 
and insufficient sterol activity.  With respect to energy 
metabolism this lipid imbalance results in oxidation out of 
control, i.e., damaging oxidative free radical reactions with 
peroxide formation.  This patient produces energy with oxygen 
but in a form that the body cannot use.  The highly energized 
oxygen radicals destroy tissues, inhibit enzyme activity and 
accelerate the degeneration/aging of tissues.

     Not a pretty picture -- both your anaerobic and your 
dysaerobic patients are suffering from severe aberrations in 
oxidative energy metabolism.  Now let us consider briefly the 
problems with membrane permeability associated with these 
imbalances.

     When we are talking about biological membranes we are 
talking about ...

                   SELECTIVE PERMEABILITY.

     Each cell of the body must be able to provide for its own 
particular needs, be it a liver cell, a muscle cell, a brain
cell, or whatever.  In addition to producing energy it must be 
able to:
                            - 4 -


- allow nutrients to penetrate through its membrane into the    
cell

- provide a barrier preventing unwanted nutrients and toxins 
from passing into the cell

- allow waste products to pass out from within the cell 
through the membrane

- to retain nutrients, enzymes and all the vital substances it 
needs to maintain its function -- not allowing them to leak 
out through the membrane

     Much of this membrane function is dependent on proper 
balance of electro-magnetic forces in the membrane.  The 
positive and negative polar groups on fatty acids and sterols 
are an important part of maintaining proper membrane polarity.

     Your anaerobic patient has insufficient fatty acids and 
excess sterols in their membranes, while your dysaerobic 
patient has excess fatty acids and insufficient sterols in 
their membrane structure.  The result in each case is an 
impairment in the membrane's functional control of selective 
permeability.

     Important nutrients cannot get into the cells while 
excesses of unwanted substances can.  Waste products cannot be 
effectively eliminated and/or unwanted substances accumulate 
to toxic levels within the cells.

     Now, we have enough understanding of Anaerobic/Dysaerobic 
imbalance to understand why each test on page two of your QRG
applies to this imbalance.  Consider first the most important 
test of all -- the urine surface tension.

     What is surface tension?  It is a physical quality of 
liquids associated with molecular adhesion at the surface.

     How does your urotensiometer (UT) measure surface 
tension?  The surface tension (ST) of a liquid inhibits the 
fall of the liquid column in the UT.  The height at which a 
fluid stops in the UT is determined by that fluid's ST -- 
i.e., its adherence to the sides of the tube.

     Distilled water has a high ST of 74 as measured by your 
UT.  Urine has a lower ST than distilled water.  Why?  Urine 
contains the end products of oxidative metabolism.  These 
metabolic end products lower the surface tension of urine to
something less than that of water.


                            - 5 -


     In a healthy, metabolically balanced person the end 
products of metabolism in the urine will decrease the ST to 
68.  In other words, the surface tension has been decreased 
enough by oxidative end products to drop the height of the 
fluid tube in the UT from 74 down to 68.

     In an anaerobic patient we know we have insufficient 
oxidative energy metabolism.  So what would you expect with 
respect to the amount of oxidative end products to be found in 
anaerobic urine?  There will be less oxidative end products in 
the urine, which means that the urinary ST will be closer to 
that of water than it would be to the ST of a metabolically 
balanced person.  In other words, the anaerobic patient's ST 
will be somewhere between 68 and 74.

     Your dysaerobic patient has oxidative stress.  What kind 
of ST would you expect to find?  A dysaerobic patient excretes 
tremendous amounts of oxidative end products in their urine.  
As a result, the ST tends to be less than 68.  No single test 
gives you more information about the status of your patients' 
quantity and quality of oxidation than the urinary ST.

     Two other essential tests to consider in analyzing 
Anaerobic/Dysaerobic imbalances are the urine pH and the 
adjusted saliva pH.  Why do these pH's relate specifically to 
this balance system?

     Dramatic pH changes occur within and without the tissues 
of your anaerobic and dysaerobic patients.  Anaerobic tissues 
are typified by excess anaerobic glycolysis.  What is one 
major end product of anaerobic metabolism?  Lactic acid is 
produced in excess quantities in anaerobic tissues.  Because 
of the abnormal membrane permeability of the anaerobic tissues 
other acids accumulate as well.  Thus, we have a powerful 
shift toward a tissue acidosis in your anaerobic patients.

     At the systemic level there is a valiant effort put forth 
to mobilize alkaline reserves to protect against the acidosis.  
As a result, your anaerobic patients present a paradoxical 
situation in which the tissues are extremely acid yet there is 
a systemic alkalosis.  This paradoxical pH imbalance is 
reflected in the high urine pH and low adjusted saliva pH.

     Your dysaerobic patient is exactly the opposite of the 
anaerobic -- there is a tissue alkalosis and a systemic 
acidosis.  How does this occur?  Remember, the dysaerobic 
patient has excess fatty acids in the tissues.  Not only are 
the fatty acids excessive in quantity, but qualitatively the
tissues tend to produce abnormal pathological fatty acids.  
The abnormal polarity of these fatty acid molecules causes
energy centers which tend to bind chloride ions.  The chloride
                            - 6 -

ions bind at the site of the double bonds in the fatty acid 
molecule.  This excess chloride fixation allows sodium to 
remain free to combine with carbonate ions forming strongly 
alkaline compounds.  As in the anaerobic patient there is a 
compensatory reaction at the systemic level in a futile 
attempt to balance the excess alkali.  This explains the 
systemic acidosis and the low urine and high saliva pH typical 
of your dysaerobic patients.

     The next test to consider on page two of your QRG is the 
specific gravity.  Why does an anaerobic patient tend to have 
low specific gravity and a dysaerobic patient high specific 
gravity?  The answer lies in the effect of anaerobic and 
dysaerobic imbalances on both the kidneys and the GI tract.

     An anaerobic imbalance causes the kidneys to pull 
excessive quantities of water out of the blood stream for 
elimination.  This explains the low specific gravity and the 
tendency to polyuria in your anaerobic patients.

     As you might expect, quite the opposite is the case with 
your dysaerobic patients.  The kidneys tend to resorb most 
water back into the blood stream, eliminating a urine which is 
extremely concentrated.  Your dysaerobic patients have high 
urinary specific gravity and a tendency to oliguria.

     In the intestines the anaerobic cells tend to pull 
excessive quantities of water out of the intestinal lumen and 
into the blood stream.  While that water heads straight for 
the kidneys for elimination, it leaves the intestinal 
environment somewhat dehydrated.  This explains the anaerobic 
patient's tendency to constipation.  The dysaerobic patient 
tends to dump excessive quantities of water into the 
intestinal tract, particularly in the duodenum via the common 
bile duct.  This leaves the body somewhat dehydrated and 
causes a tendency to diarrhea in your dysaerobic patients.

     Think of it this way -- your anaerobic patients lose 
excessive water through the kidneys, while your dysaerobic 
patients lose excessive water through the GI tract.

     Now that you have a basic understanding of Anaerobic/ 
Dysaerobic metabolism take another look at the list of 
Anaerobic/Dysaerobic conditions on page one.  When your 
patient has one of these symptoms associated with an anaerobic 
or a dysaerobic imbalance there is only one way you can 
correct the cause -- with page two of your NUTRI-SPEC QRG.


                        Sincerely,

                        Guy R. Schenker, D.C.


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