From: Guy R. Schenker, D.C. June, 1999 Dear Doctor, You have seen that most of your patients with an electrolyte insufficiency imbalance are ... STUCK IN LOW GEAR. When the physical and emotional demands of life require that they punch down the accelerator and zoom joyfully down the highway of life -- they are stuck in the slow lane behind a truck, choking on its exhaust. Which of your highly bio-active NUTRI-SPEC supplements will give the most immediate and dramatic vitality boost to your EI patients? You learned last month that it is very often your Formula EW -- which is primarily glycerol plus a little vitamin E. Why is glycerol such a powerful therapeutic tool? - It not only influences fluid dynamics but influences membrane permeability as well. It quickly permeates all three body fluid compartments, carrying electrolyte buffers and other solutes, along with biologically activated water to meet physiological demand. - Glycerol also binds with and neutralizes the free fatty acids that are the primary cause of the aging process which results from free radical peroxidation -- particularly the abnormal fatty acids with conjugated double bonds which most accelerate the aging process. In other words, glycerol effectively reverses the essence of the pathological process that defines our NUTRI-SPEC Electrolyte Insufficiency imbalance. It is particularly crucial to your EI patients who have a strong oxidative stress (dysaerobic) component to their EI imbalance. - 2 - The combination of pathological processes which typify an EI imbalance (involving fluid and electrolyte dynamics plus free radical peroxidation), allows us to picture the whole electrolyte insufficiency imbalance as resembling a sub-clinical state of shock. This model was first proposed by Rivici many years ago. Both the free radical damage and the aberrant fluid dynamics of your EI patients are precisely the findings in patients with either heat shock or hemmorhagic shock, just milder in degree. Based originally on this Rivici model of mild shock accompanying low adrenal and kidney function, and the resulting stress on the vascular system -- NUTRI-SPEC has been using glycerol as a therapeutic agent since 1984. Now, many years later, we have quite substantial additional evidence in the scientific literature supporting glycerol's clinical benefits. One study was published in Medicine and Science in Sports Medicine in 1990. It was published under the title, "Effects of Glycerol Induced Hyper-Hydration prior to Exercise in the Heat On Sweating and Core Temperature." This study and others supporting it showed a tremendous increase in endurance exercise tolerance when athletes loaded with glycerol and water prior to competition. I would not be surprised if, based on the latest scientific studies, many companies in the nutrition supplement industry will jump on the band wagon and begin offering glycerol supplements. Remember that NUTRI-SPEC has been using glycerol as a therapeutic agent for more than 15 years. We have pioneered its use and have very specific objective protocol indicating when it is beneficial and when it will do harm. Do harm? How can a supplement whose clinical power I just raved about possibly cause harm? Remember, you are a NUTRI-SPEC practitioner. That means you understand the concept of biological individuality. Any therapeutic agent that has the power to correct one patient's metabolic imbalance has the potential to harm a patient with the opposite metabolic imbalance. Glycerol has a powerful alkalizing effect on the systemic level of biological organization, and a powerful acidifying effect at the tissue level. Any patient who has an anaerobic imbalance as a primary cause of their symptoms will see those symptoms greatly exacerbated by glycerol. - 3 - Do you begin to appreciate the beauty of your Quick Reference Guide (QRG) analysis of your patients' test results? You have specific objective protocol for each highly bio-active NUTRI-SPEC supplement, including Formula EW. You know exactly which patients will benefit from its therapeutic affect, and which patients will be harmed. Furthermore, you know exactly how much is likely to be beneficial and what other nutrients must accompany it to maintain balance. In the last several months we have completed our discussion of electrolyte insufficiency and electrolyte stress imbalances as they relate to the sweeping changes made last year in your QRG analysis. Our discussion of glycerol leads us easily from our discussion of electrolyte and fluid dynamics into a discussion of our second fundamental metabolic control system ... ANAEROBIC/DYSAEROBIC BALANCE. Your NUTRI-SPEC Anaerobic/Dysaerobic balance system is based upon the paradigm developed by Emmanuel Rivici. Dr. Rivici was unique in being both a world class molecular biologist and a world class clinician. From studying Rivici's work we know that anaerobic/dysaerobic problems can be thought of in two ways: - an imbalance in oxidative metabolism - an imbalance in lipid metabolism Furthermore, Rivici showed that oxidative metabolism and lipid metabolism are functionally related in two ways: - to produce energy with oxygen efficiently - to control membrane permeability Are we talking about anything important here? When we talk about oxidative energy production and the selective permeability of biological membranes we are talking about ... THE ESSENCE OF LIFE ITSELF. That is why anaerobic/dysaerobic balance is the most pervasive of your five NUTRI-SPEC metabolic control systems. Without strength and balance in both anti- anaerobic and anti-dysaerobic forces, your patient cannot: - produce oxidative energy in sufficient quantity to power the essential activities of a high vitality life. - 4 - - prevent the oxidative free radical damage that accelerates tissue degeneration and aging. - maintain glycemic control. - maintain normal fluid and electrolyte dynamics in each of the three body fluid compartments. - maintain normal pH in each of the three body fluid compartments. In other words, anaerobic/dysaerobic forces play a part in virtually everything that happens in the human body. That is also why virtually any symptom or condition you can name is likely to have an anaerobic or a dysaerobic component. How difficult is it to find and treat an imbalance in this vitally important metabolic control system? Finding it takes less than 20 seconds using your QRG. Treating it is as simple as selecting from only a half dozen supplements as per your QRG protocol. Look at your QRG now. Look at the anaerobic/ dysaerobic section of page one and just imagine that you as a clinician so easily have ... POWER OVER THE ESSENCE OF LIFE. Look at the 3-point quick scan. These three tests, the surface tension, the oxidative index and the adjusted urine pH allow you in less than 10 seconds to eliminate this imbalance from consideration if your patient has no obvious problem here. If you do find a potential problem when considering this 3-point Quick Scan you need only consider two additional tests -- the adjusted saliva pH and the dermographics line to either confirm or rule out the need for an anaerobic/dysaerobic treatment regimen for this patient. Having found an anaerobic/dysaerobic imbalance, you need take another minute to work through the anaerobic/ dysaerobic supplement page of your QRG to determine which of the five supplements your patient needs and in exactly what quantities. And what amazing supplements they are. Pick up a bottle of Oxygenic A and a bottle of Oxygenic D. Read through the lists of ingredients and ask yourself just what it all means. Oxygenic A gives your - 5 - anaerobic patient every vitamin, every mineral, every trace mineral and every amino acid needed to reverse the causes and the effects of insufficient oxidative energy production. Similarly, Oxygenic D provides all the vitamins, all the minerals, all the trace minerals and all the amino acids essential to reverse the causes and effects of free radical peroxidation. Now consider your Oxygenic A-Plus and Oxygenic D-Plus. THESE ARE THE CLOSEST THING TO MAGIC YOU WILL EVER FIND. While the Oxy A and Oxy D provide the nutrient raw materials, it is the Oxy A-Plus and the Oxy D-Plus which drive the mechanism. By that I mean two things: - The membrane permeability is repolarized such that fluid and solutes (including all the juicy ingredients of Oxy A or Oxy D) are able to flow to their site of activity. - The spark is provided to fire up the metabolic engine -- Think of the Oxy A and D as the fuel being sucked into a car's engine, while the Oxy A+ and D+ are the spark that ignites the fuel. You cannot correct your anaerobic/dysaerobic patients with Oxy A and Oxy D alone any more than you can make your car run by dousing the engine with a gallon of gasoline. The fuel has to be put exactly where it needs to be and must be energized. That is the role of your Oxygenic A+ and D+. These are the therapeutic agents that make the typical clinical nutritionist look impotent compared to you and NUTRI-SPEC. Consider that Rivici tested literally hundreds of biologically active substances for their metabolic effects. Out of all those substances he selected the ingredients of your Oxygenic A+ and Oxygenic D+ to use for their powerful and immediate impact on body chemistry. He used these two supplements exclusively for nearly 40 years as his sole means of controlling metabolic balance at the tissue and systemic levels. Let us look just a bit closer. Consider Oxygenic D+. Recall all that was said above about the effects of glycerol in your Formula EW in its control of fluid and electrolyte dynamics, tissue pH and the neutralization of free radical peroxidation. Glycerol is just one ingredient of Oxygenic D+. Everything that was said above - 6 - regarding glycerol applies to Oxygenic D+. Take the anti-dysaerobic power of Formula EW and multiply it perhaps by 10 and that is what you have with Oxygenic D+. OXYGENIC D+ IS THE ULTIMATE ANTI-OXIDANT. And what about Oxygenic A+? Here you have a combination of magnesium (arguably the most clinically important of all the macro minerals) combined with negative valence sulfur. The negative valence sulfur is the key to innumerable biochemical processes. It constitutes the active functional group in such diverse compounds as glutathione, cysteine, taurine, and methionine. Just think of it as promoting normal oxidation, while protecting against the tissue damage that accrues from insufficient oxidation. It is no exaggeration to say that you could build an entire nutrition practice on nothing more than the judicious use of Oxygenic A-Plus and Oxygenic D-Plus (plus Oxy B to provide trace minerals, of course). Glancing at the rest of your QRG page for Anaerobic/Dysaerobic supplementation you see three other supplements that are frequently a useful adjunct for either your anaerobic or dysaerobic patients. These other supplements are already critical ingredients in your Oxygenic A or Oxygenic D. Many patients, however, will benefit at least temporarily from extra dosages of these supplements. These are so amazing in their clinical power that each one could be the subject of an entire issue of this Letter. Use them according to your QRG protocol and you will be astounded at their clinical impact (particularly when they accompany Oxy A+ or Oxy D+). Clinical excellence is easily attainable (but only attainable) when you are guided by objective test procedures. When you can objectively quantify each patient's status with respect to fundamental metabolic control systems, and then -- as you can with NUTRI-SPEC supplements -- restore strength and balance to those control systems, you have the basis of a highly successful practice -- effectively serving a broad diversity of enthusiastic patients. Sincerely, Guy R. Schenker, D.C.