From:
Guy R. Schenker, D.C.
March, 1997


Dear Doctor,

     Do you have any patients with ...

                CHRONIC FATIGUE SYNDROME?

Never mind an "official" diagnosis of chronic fatigue 
syndrome -- Do your patients ever complain of just being 
too tired too much of the time?  It is likely that many if 
not most of your patients drag themselves through day 
after weary day with no idea how to regain the vitality
long lost.

     You can give them the boost they need with 
NUTRI-SPEC.  And in many of these cases the boost they 
need consists of ...

    CORRECTING AN ELECTROLYTE INSUFFICIENCY IMBALANCE.

     In the February, 1996 issue of this Letter we cited a 
fascinating research study out of Johns Hopkins 
University.  It was reported in the Journal of the 
American Medical Association that they had discovered an 
amazing treatment for chronic fatigue syndrome that 
resulted in improved energy levels in 76% of the patients 
so afflicted.

     What was the keystone of this phenomenally successful 
treatment for chronic fatigue syndrome?  Nothing more 
exotic than common table salt.  Think of it -- 76% of 
chronic fatigue suffers felt significantly better doing 
nothing more than supplementing with salt.  What the Johns 
Hopkins findings mean in NUTRI-SPEC terms is that these 
patients had an Electrolyte Insufficiency Imbalance.




                          - 2 -


     Fatigue is one of the most common major complaints 
among our electrolyte insufficiency patients.

  BUT WITH NUTRI-SPEC YOU CAN BE FAR MORE SOPHISTICATED
       AND FAR MORE EFFECTIVE IN YOUR TREATMENT OF
     THESE PATIENTS THAN THEY WERE AT JOHNS HOPKINS.

     You have a very specific and comprehensive protocol 
listed on the first page of your newly revised Quick 
Reference Guide.  Your NUTRI-SPEC approach to electrolyte 
insufficiency addresses far more than the poor mineral 
retention and resulting low salt levels of these fatigued 
patients.

     You have at your disposal many different mineral 
salts, plus several vitamin and mineral complexes, plus 
several pure form amino acids -- each to correct whatever 
aspects of mineral depletion apply to each particular 
patient.

     We ended last month's Letter in the middle of a 
discussion of your newly revised Electrolyte Stress and 
Electrolyte Insufficiency page of your Quick Reference 
Guide.  You learned how to pull four numbers off your 
patient's test results form and carry them over to your 
Quick Reference Guide page to determine in 10 seconds or 
less whether your patient has an Electrolyte Stress or an 
Electrolyte Insufficiency imbalance.

     Suppose you have found an Electrolyte Insufficiency 
imbalance in a patient.  You have a long list of potential 
supplements to consider.  The criteria indicating the need 
for each of these supplements is very specific.  The 
protocol was designed to give each electrolyte 
insufficiency patient just the support they need, where 
they need it.

     For example, some electrolyte insufficient patients 
are largely a problem with low levels of the hormone 
renin; in others the major hormone involvement is adrenal; 
and in still others it is largely a sex hormone problem.  
Each of these and many other contributing factors to the 
Electrolyte Insufficiency imbalance are specifically 
supported by your QRG protocol.

     Among the supplements to consider for electrolyte 
insufficiency are three pure form amino acids.  Let us 
take a look at these, beginning with Phenylalanine.



                          - 3 -


     Phenylalanine will give a tremendous lift to many of 
your electrolyte insufficient patients.  It will eliminate 
their fatigue and reduce any depression associated with 
that fatigue.  It will also raise their blood pressure and 
decrease the mental fog that frequently accompanies an
electrolyte insufficiency.

     One of the best studies I have seen on chronic 
fatigue syndrome evaluated the levels of the essential 
amino acids in patients with chronic fatigue.  This study 
did nothing more complicated than supplement chronic 
fatigue patients with the amino acids in which they were 
low according to serum levels.  More then 75% of the test 
group showed either very good or excellent improvement in 
symptoms with nothing more than amino acid supplementation  

     Of all the amino acids studied, Phenylalanine was by 
far the most clinically significant.

        FULLY 72% OF THE CHRONIC FATIGUE SUFFERERS
             IN THIS STUDY WERE FOUND TO HAVE
               LOW LEVELS OF PHENYLALANINE.

Many of these patients also suffered from depression.  The 
fatigue and depression resolved in the vast majority of 
these patients with phenylalanine supplementation.

     Phenylalanine serves as a precursor to catecholamines 
and serotonin, neurotransmitters that are specifically 
associated with depressive disorders.  Another study 
published in the American Journal of Psychiatry showed 
that phenylalanine supplementation was effective in over 
coming depression.  Phenylalanine has this effect by 
increasing levels of phenylethylamine, which are low in 
patients with depression.

     There are many other benefits of phenylalanine that 
will be discussed in future Letters when we talk about the 
benefits of phenylalanine for your patients with 
Glucogenic, Ketogenic, Parasympathetic, and Acid 
imbalances.  But for now, when you see an electrolyte 
insufficient patient with a high Adjusted Saliva pH and a 
slow first pulse, think ...

              PHENYLALANINE TO REVERSE THEIR

                      - FATIGUE
                      - DEPRESSION
                      - MENTAL FOG
                      - LOW BLOOD PRESSURE
                      - LOW BLOOD SUGAR
                          - 4 -


     Tyrosine is another pure form amino acid beneficial 
for many of your electrolyte insufficiency patients.  
Tyrosine can actually be derived from phenylalanine.  
Phenylalanine becomes tyrosine, becomes L-Dopa, becomes 
Dopamine, becomes Norepinepherine, becomes Epinepherine.  
Tyrosine, like phenylalanine, is very effective for 
patients with fatigue and/or depression.

       TYROSINE IS A VERY EFFECTIVE ANTI-DEPRESSANT
     AND DOES NOT CAUSE THE CHOLINERGIC SIDE EFFECTS
           COMMON TO TRICYCLIC ANTI-DEPRESSANTS
                   AND MAO INHIBITORS.

     One of the most convincing studies on the effect of 
Tyrosine on fatigue was actually done on a group of 
patients suffering from narcolepsy.  Narcolepsy (and to a 
certain extent many forms of fatigue) is associated with 
abnormalities of the dopaminergic system.  The study,  
published in the Lancet, showed that within six months of 
Tyrosine supplementation every narcoleptic was free from 
day time sleep attacks as well as episodes of catoplexy.

     Studies have shown other remarkable clinical effects 
from Tyrosine supplementation.  It has a significant 
anti-histamine effect and benefits allergies.  Tyrosine 
reverses anemia by increasing both low RBC and low WBC 
counts.  It has also been demonstrated to increase 
sub-normal thyroid activity (as has phenylalanine).

     Tyrosine will be discussed further in future Letters 
as it relates to Anaerobic, Glucogenic, Ketogenic, 
Parasympathetic, Acid and Alkaline patients as well.  
Meanwhile, for any of your electrolyte insufficient 
patients with a high Adjusted Saliva pH and a strong 
Breath Hold Time, give them ...

             TYROSINE TO REVERSE THEIR

                  - FATIGUE
                  - DEPRESSION
                  - LOW BLOOD PRESSURE
                  - ANEMIA
                  - ALLERGIES
                  - LOW BLOOD SUGAR

     Glutamine is another of your new products that is 
indispensable for certain Electrolyte Insufficiency 
patients.  Glutamine plays an anabolic role in that it 
stimulates human muscle glycogen synthesis following


                          - 5 -


exercise.  Glutamine also reverses the catabolic effect on 
muscles due to excess glucocorticoids (or to low levels of 
androgens with respect to glucocorticoids).  Glutamine is 
more important than any other amino acid in maintaining
nitrogen balance.  In other words, adequate glutamine is 
essential to prevent protein wasting.  Glutamine 
supplementation has been shown to result in increased 
circulating plasma growth hormone concentration.  
Glutamine has also been used to successfully treat 
impotence.

     This protein anabolic effect is critical for many of 
your electrolyte insufficient patients as they frequently 
suffer the weakness associated with excess catabolism.

     Glutamine is also essential for the acid/alkaline 
component of many electrolyte insufficiency problems.  
Many of your electrolyte insufficient patients are 
continuously on the borderline of a potassium excess 
acidosis or an adrenal acidosis.  Glutamine 
supplementation results in an increased level of plasma 
bicarbonate.  A surprisingly small oral glutamine dose is 
capable of elevating alkaline reserves (as well as plasma 
growth hormone).

     Another major benefit from glutamine is that it 
passes the blood-brain barrier, while glutamic acid does 
not.  After passing into the brain glutamine is 
transformed into glutamic acid.  Glutamic acid is one of 
the few substances other than glucose that the brain can 
use as fuel.  Glutamine (by conversion to glutamic acid in 
the brain) can prevent fatigue and depression and 
increases mental acuity.  (Glutamine has also been 
beneficial for elderly patients with senility and 
associated psychiatric illness.)  Low glutamine levels are 
strongly correlated with premature aging.

     We will talk more about glutamine in our discussions 
of Dysaerobic, Glucogenic, Parasympathetic, and Acid 
imbalances in the months ahead.  Particularly, you will 
learn of glutamine's amazing role in maintaining G.I. 
function and its clinical use for ulcers, colitis and gall 
bladder problems.  But begin using Glutamine immediately 
for electrolyte insufficient patients with a high Adjusted 
Saliva pH and a weak Breath Hold Time as ...






                          - 6 -


               GLUTAMINE WILL REVERSE THEIR

                      - FATIGUE
                      - DEPRESSION
                      - PROTEIN WASTING
                      - ACIDOSIS
                      - MENTAL FOG
                      - LOW BLOOD SUGAR

     Now, you know how to find an Electrolyte 
Insufficiency in 10 seconds or less.  You know how to use 
your QRG to pick just the supplements indicated for each 
of your electrolyte insufficient patients.  Having given 
an EI patient everything they need to begin re-charging 
their depleted battery, you must now effectively manage 
their recovery.

     As always, you will do your first NUTRI-SPEC 
follow-up testing within a week.  At that point they may 
already need changes in their supplement regimen.

     Remember, the criteria for prescribing your 
supplements are very specific.  Suppose the indications 
for a supplement you prescribed on the first testing are 
no longer met?  What do you do?  Simply decrease the 
dosage.  If the supplement was an electrolyte, reduce the 
dosage from 1/4 to 1/8 teaspoon.  If the supplement was an 
amino acid, reduce the dosage from 2 capsules, twice daily 
before meals to 3 capsules before breakfast.

     Suppose on the follow-up test a supplement is 
indicated that was not indicated upon initial testing?  
Simply add that supplement now.

     We have spoken often in these Letters of electrolyte 
insufficiency patients as those who have absolutely no 
power in their punch -- hypotonic weaklings -- a deflated 
balloon, begging for you to pump them up.  With your new 
QRG protocol you have everything you need to get these 
patients started on the road to high vitality.


                        Sincerely,




                        Guy R. Schenker, D.C.

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